Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM66074
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay
IC50
1080±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM66074
Synonyms:
4-methylbenzenecarbothioic acid S-(7-oxo-1-cyclohepta-1,3,5-trienyl) ester | 4-methylthiobenzoic acid S-(7-ketocyclohepta-1,3,5-trien-1-yl) ester | MLS001173246 | S-(7-oxidanylidenecyclohepta-1,3,5-trien-1-yl) 4-methylbenzenecarbothioate | S-(7-oxocyclohepta-1,3,5-trien-1-yl) 4-methylbenzenecarbothioate | SMR000539107 | cid_917183
Type:
Small organic molecule
Emp. Form.:
C15H12O2S
Mol. Mass.:
256.32
SMILES:
Cc1ccc(cc1)C(=O)Sc1cccccc1=O
Structure:
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