Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM67336
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay
IC50
3560±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM67336
Synonyms:
(3E)-4-bromo-3-[(4-ethoxyphenyl)imino]-5-methyl-1,3-dihydro-2H-indol-2-one | 4-bromanyl-3-[(4-ethoxyphenyl)amino]-5-methyl-indol-2-one | 4-bromo-3-(4-ethoxyanilino)-5-methyl-2-indolone | 4-bromo-3-(4-ethoxyanilino)-5-methylindol-2-one | 4-bromo-5-methyl-3-(p-phenetidino)indol-2-one | MLS001194938 | SMR000554760 | cid_1380474
Type:
Small organic molecule
Emp. Form.:
C17H15BrN2O2
Mol. Mass.:
359.217
SMILES:
CCOc1ccc(NC2=c3c(Br)c(C)ccc3=NC2=O)cc1 |c:8,17|
Structure:
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