Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM67388
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay
IC50
2140±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM67388
Synonyms:
2-bromanyl-N'-(4,6-dimethylpyrimidin-2-yl)-4,6-bis(fluoranyl)benzenesulfonohydrazide | 2-bromo-N'-(4,6-dimethyl-2-pyrimidinyl)-4,6-difluorobenzenesulfonohydrazide | 2-bromo-N'-(4,6-dimethylpyrimidin-2-yl)-4,6-difluoro-benzenesulfonohydrazide | 2-bromo-N'-(4,6-dimethylpyrimidin-2-yl)-4,6-difluorobenzenesulfonohydrazide | MLS002244974 | SMR001308643 | cid_2539399
Type:
Small organic molecule
Emp. Form.:
C12H11BrF2N4O2S
Mol. Mass.:
393.207
SMILES:
Cc1cc(C)nc(NNS(=O)(=O)c2c(F)cc(F)cc2Br)n1
Structure:
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