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Target
NADPH oxidase 1
Ligand
BDBM67554
Substrate
n/a
Meas. Tech.
Late-stage luminescence-based cell-based dose response assay to identify inhibitors of NADPH oxidase 1 (NOX1): Purchased analogs 2
IC50
2944±n/a nM
Citation
 PubChem, PC Late-stage luminescence-based cell-based dose response assay to identify inhibitors of NADPH oxidase 1 (NOX1): Purchased analogs 2 PubChem Bioassay (2010)[AID] 
Target
Name:
NADPH oxidase 1
Synonyms:
MOX-1 | MOX1 | Mitogenic oxidase 1 | NADH/NADPH mitogenic oxidase subunit P65-MOX | NOH-1 | NOH1 | NOX-1 | NOX1 | NOX1_HUMAN
Type:
PROTEIN
Mol. Mass.:
64890.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_792877
Residue:
564
Sequence:
MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVIMTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF
  
Inhibitor
Name:
BDBM67554
Synonyms:
2,6-dimethoxy-4-[[(2,3,5,6-tetrafluoro-4-pyridinyl)hydrazo]methylidene]-1-cyclohexa-2,5-dienone | 2,6-dimethoxy-4-[[2-(2,3,5,6-tetrafluoropyridin-4-yl)hydrazinyl]methylidene]cyclohexa-2,5-dien-1-one | 2,6-dimethoxy-4-[[2-[2,3,5,6-tetrakis(fluoranyl)pyridin-4-yl]hydrazinyl]methylidene]cyclohexa-2,5-dien-1-one | 2,6-dimethoxy-4-[[N'-(2,3,5,6-tetrafluoro-4-pyridyl)hydrazino]methylene]cyclohexa-2,5-dien-1-one | SR-03000000888-1 | cid_9514690
Type:
Small organic molecule
Emp. Form.:
C14H11F4N3O3
Mol. Mass.:
345.2491
SMILES:
COc1cc(CN=Nc2c(F)c(F)nc(F)c2F)cc(OC)c1O |w:6.5|
Structure:
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