Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase 33
Ligand
BDBM50068
Substrate
n/a
Meas. Tech.
Luminescence Cell-Free Homogenous Dose Retest to Identify Inhibitors of Serine/Threonine Kinase 33 Activity
EC50
8621±n/a nM
Citation
 PubChem, PC Luminescence Cell-Free Homogenous Dose Retest to Identify Inhibitors of Serine/Threonine Kinase 33 Activity PubChem Bioassay (2010)[AID] 
Target
Name:
Serine/threonine-protein kinase 33
Synonyms:
STK33 | STK33_HUMAN | Serine/threonine-protein kinase 33
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57833.21
Organism:
Homo sapiens (Human)
Description:
gi_23943882
Residue:
514
Sequence:
MADSGLDKKSTKCPDCSSASQKDVLCVCSSKTRVPPVLVVEMSQTSSIGSAESLISLERKKEKNINRDITSRKDLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENGAAIEEIYTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCAKSVLKQLMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVEENTTEEKNKPSTEEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQFPATSKDNFDMCSSSFTSSKLLPAEIKGEMEKTPVTPSQGTATKYPAKSGALSRTKKKL
  
Inhibitor
Name:
BDBM50068
Synonyms:
(5E)-3-amino-5-[(2E)-1-cyano-2-(3-ethoxy-4-keto-cyclohexa-2,5-dien-1-ylidene)ethylidene]-3-pyrazoline-4-carbonitrile | (5E)-3-amino-5-[(2E)-1-cyano-2-(3-ethoxy-4-oxo-1-cyclohexa-2,5-dienylidene)ethylidene]-1,2-dihydropyrazole-4-carbonitrile | (5E)-3-amino-5-[(2E)-1-cyano-2-(3-ethoxy-4-oxocyclohexa-2,5-dien-1-ylidene)ethylidene]-1,2-dihydropyrazole-4-carbonitrile | (5E)-3-azanyl-5-[(2E)-1-cyano-2-(3-ethoxy-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)ethylidene]-1,2-dihydropyrazole-4-carbonitrile | 5-Amino-3-[1-cyano-2-(3-ethoxy-4-hydroxy-phenyl)-vinyl]-1H-pyrazole-4-carbonitrile | MLS000523215 | SMR000123193 | cid_9549349
Type:
Small organic molecule
Emp. Form.:
C15H13N5O2
Mol. Mass.:
295.296
SMILES:
CCOc1cc(C=C(C#N)c2n[nH]c(N)c2C#N)ccc1O |w:6.5|
Structure:
Search PDB for entries with ligand similarity: