Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM57106
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
2080±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM57106
Synonyms:
Hydroxy-bis-(3-trifluoromethyl-phenyl)-acetic acid N'-(2-bromo-phenyl)-hydrazide | MLS000554211 | N'-(2-bromophenyl)-2-hydroxy-2,2-bis[3-(trifluoromethyl)phenyl]acetohydrazide | N'-(2-bromophenyl)-2-oxidanyl-2,2-bis[3-(trifluoromethyl)phenyl]ethanehydrazide | SMR000146528 | cid_1896987
Type:
Small organic molecule
Emp. Form.:
C22H15BrF6N2O2
Mol. Mass.:
533.261
SMILES:
OC(C(=O)NNc1ccccc1Br)(c1cccc(c1)C(F)(F)F)c1cccc(c1)C(F)(F)F
Structure:
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