Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM67836
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
>10000±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM67836
Synonyms:
3-(phenylcarbonyl)-2-(trifluoromethyl)benzo[f][1]benzofuran-4,9-dione | 3-benzoyl-2-(trifluoromethyl)benzo[f][1]benzofuran-4,9-dione | 3-benzoyl-2-(trifluoromethyl)benzo[f]benzofuran-4,9-dione | 3-benzoyl-2-(trifluoromethyl)benzo[f]benzofuran-4,9-quinone | 3-benzoyl-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione | MLS000533785 | SMR000141223 | cid_1207959
Type:
Small organic molecule
Emp. Form.:
C20H9F3O4
Mol. Mass.:
370.2783
SMILES:
FC(F)(F)c1oc2c(c1C(=O)c1ccccc1)C(=O)c1ccccc1C2=O
Structure:
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