Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM41613
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
4990±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM41613
Synonyms:
5-bromanyl-N-[[3-(4-methylphenyl)-1-phenyl-pyrazol-4-yl]methylideneamino]furan-2-carboxamide | 5-bromo-N'-{[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-2-furohydrazide | 5-bromo-N-[[1-phenyl-3-(p-tolyl)pyrazol-4-yl]methyleneamino]-2-furamide | 5-bromo-N-[[3-(4-methylphenyl)-1-phenyl-4-pyrazolyl]methylideneamino]-2-furancarboxamide | 5-bromo-N-[[3-(4-methylphenyl)-1-phenylpyrazol-4-yl]methylideneamino]furan-2-carboxamide | MLS000570981 | SMR000187045 | cid_1365339
Type:
Small organic molecule
Emp. Form.:
C22H17BrN4O2
Mol. Mass.:
449.3
SMILES:
Cc1ccc(cc1)-c1nn(cc1C=NNC(=O)c1ccc(Br)o1)-c1ccccc1 |w:13.15|
Structure:
Search PDB for entries with ligand similarity: