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Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM54739
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
310±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
DDIT3_MOUSE | Ddit3 | Chop | Chop10 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mouse
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM54739
Synonyms:
3-[[1-(4-fluorophenyl)-5-tetrazolyl]thio]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione | SMR000293005 | MLS000663719 | 3-[[1-(4-fluorophenyl)-1,2,3,4-tetrazol-5-yl]sulfanyl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione | 3-{[1-(4-fluorophenyl)-1H-tetrazol-5-yl]thio}-1-(4-methoxyphenyl)-2,5-pyrrolidinedione | cid_2945197 | 3-[1-(4-fluorophenyl)tetrazol-5-yl]sulfanyl-1-(4-methoxyphenyl)pyrrolidine-2,5-dione | 3-[[1-(4-fluorophenyl)tetrazol-5-yl]thio]-1-(4-methoxyphenyl)pyrrolidine-2,5-quinone
Type:
Small organic molecule
Emp. Form.:
C18H14FN5O3S
Mol. Mass.:
399.08
SMILES:
COc1ccc(cc1)-n1c(O)cc(Sc2nnnn2-c2ccc(F)cc2)c1O
Structure:
Search PDB for entries with ligand similarity: