Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM68189
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
>10000±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM68189
Synonyms:
5-(6-methyl-2-imidazo[1,2-a]pyridinyl)-3-phenylisoxazole | 5-(6-methylimidazo[1,2-a]pyridin-2-yl)-3-phenyl-1,2-oxazole | 5-(6-methylimidazo[1,2-a]pyridin-2-yl)-3-phenyl-isoxazole | 6-methyl-2-(3-phenyl-5-isoxazolyl)imidazo[1,2-a]pyridine | MLS000860564 | SMR000458648 | cid_2813808
Type:
Small organic molecule
Emp. Form.:
C17H13N3O
Mol. Mass.:
275.3046
SMILES:
Cc1ccc2nc(cn2c1)-c1cc(no1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: