Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM33167
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
EC50
3356±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM33167
Synonyms:
4-(2-chloranyl-5-ethenylsulfinyl-4-nitro-thiophen-3-yl)morpholine | 4-(2-chloro-4-nitro-5-vinylsulfinyl-3-thienyl)morpholine | 4-(2-chloro-5-ethenylsulfinyl-4-nitro-3-thiophenyl)morpholine | 4-(2-chloro-5-ethenylsulfinyl-4-nitrothiophen-3-yl)morpholine | 4-[2-chloro-4-nitro-5-(vinylsulfinyl)-3-thienyl]morpholine | MLS000672192 | SMR000293370 | cid_2948526
Type:
Small organic molecule
Emp. Form.:
C10H11ClN2O4S2
Mol. Mass.:
322.788
SMILES:
[O-][N+](=O)c1c(sc(Cl)c1N1CCOCC1)S(=O)C=C
Structure:
Search PDB for entries with ligand similarity: