Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM58440
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
EC50
2903±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM58440
Synonyms:
2-[[5-(2-ethyl-5-methyl-3-pyrazolyl)-4-methyl-1,2,4-triazol-3-yl]thio]-5-nitrothiazole | 2-[[5-(2-ethyl-5-methyl-pyrazol-3-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-5-nitro-1,3-thiazole | 2-[[5-(2-ethyl-5-methyl-pyrazol-3-yl)-4-methyl-1,2,4-triazol-3-yl]thio]-5-nitro-thiazole | 2-[[5-(2-ethyl-5-methylpyrazol-3-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-5-nitro-1,3-thiazole | MLS001182319 | SMR000568079 | cid_2744279
Type:
Small organic molecule
Emp. Form.:
C12H13N7O2S2
Mol. Mass.:
351.407
SMILES:
CCn1nc(C)cc1-c1nnc(Sc2ncc(s2)[N+]([O-])=O)n1C
Structure:
Search PDB for entries with ligand similarity: