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Target
Polyadenylate-binding protein 1
Ligand
BDBM53193
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (PABP)
IC50
1320±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2010)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM53193
Synonyms:
4-tert-butyl-N-(5-quinolinyl)benzamide | 4-tert-butyl-N-(5-quinolyl)benzamide | 4-tert-butyl-N-quinolin-5-yl-benzamide | 4-tert-butyl-N-quinolin-5-ylbenzamide | MLS001233705 | SMR000596113 | cid_2103217
Type:
Small organic molecule
Emp. Form.:
C20H20N2O
Mol. Mass.:
304.3856
SMILES:
CC(C)(C)c1ccc(cc1)C(=O)Nc1cccc2ncccc12
Structure:
Search PDB for entries with ligand similarity: