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Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM74454
Substrate
n/a
Meas. Tech.
Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2
IC50
>79400±0 nM
Citation
 PubChem, PC Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2 PubChem Bioassay (2010)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM74454
Synonyms:
(3,5-dimethyl-1,2-oxazol-4-yl)methyl 5-(azepan-1-ylsulfonyl)-2-methoxy-benzoate | (3,5-dimethyl-1,2-oxazol-4-yl)methyl 5-(azepan-1-ylsulfonyl)-2-methoxybenzoate | 5-(1-azepanylsulfonyl)-2-methoxybenzoic acid (3,5-dimethyl-4-isoxazolyl)methyl ester | 5-(azepan-1-ylsulfonyl)-2-methoxy-benzoic acid (3,5-dimethylisoxazol-4-yl)methyl ester | MLS000081730 | SMR000062942 | cid_2998479
Type:
Small organic molecule
Emp. Form.:
C20H26N2O6S
Mol. Mass.:
422.495
SMILES:
COc1ccc(cc1C(=O)OCc1c(C)noc1C)S(=O)(=O)N1CCCCCC1
Structure:
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