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Target
Kappa-type opioid receptor
Ligand
BDBM75418
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3
EC50
4060±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM75418
Synonyms:
2-[4-benzyl-5-[(4-bromobenzyl)thio]-1,2,4-triazol-3-yl]pyridine | 2-[4-benzyl-5-[(4-bromophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]pyridine | 2-[5-[(4-bromophenyl)methylsulfanyl]-4-(phenylmethyl)-1,2,4-triazol-3-yl]pyridine | 2-[5-[(4-bromophenyl)methylthio]-4-(phenylmethyl)-1,2,4-triazol-3-yl]pyridine | KSC-12-171-B3 | KUC105580N | cid_45479189
Type:
Small organic molecule
Emp. Form.:
C21H17BrN4S
Mol. Mass.:
437.355
SMILES:
Brc1ccc(CSc2nnc(-c3ccccn3)n2Cc2ccccc2)cc1
Structure:
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