Reaction Details Report a problem with these data
Target
Intestinal-type alkaline phosphatase
Ligand
BDBM75643
Substrate
n/a
Meas. Tech.
Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay
EC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM75643
Synonyms:
(2Z)-3-hydroxy-1-(5-hydroxy-3-methyl-1-{4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-1H-pyrazol-4-yl)but-2-en-1-one | 4-(1-hydroxy-3-keto-but-1-enyl)-5-methyl-2-[4-[3-(trifluoromethyl)phenyl]thiazol-2-yl]-3-pyrazolin-3-one | 4-(1-hydroxy-3-oxobut-1-enyl)-5-methyl-2-[4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-1H-pyrazol-3-one | 4-(1-hydroxy-3-oxobut-1-enyl)-5-methyl-2-[4-[3-(trifluoromethyl)phenyl]-2-thiazolyl]-1H-pyrazol-3-one | 5-methyl-4-(1-oxidanyl-3-oxidanylidene-but-1-enyl)-2-[4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-1H-pyrazol-3-one | MLS001143835 | SMR000473274 | cid_1473338
Type:
Small organic molecule
Emp. Form.:
C18H14F3N3O3S
Mol. Mass.:
409.382
SMILES:
CC(=O)CC(=O)c1c(C)[nH]n(-c2nc(cs2)-c2cccc(c2)C(F)(F)F)c1=O
Structure:
Search PDB for entries with ligand similarity: