Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM50169
Substrate
n/a
Meas. Tech.
Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor
IC50
3628±497 nM
Citation
 PubChem, PC Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor PubChem Bioassay (2010)[AID] 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM50169
Synonyms:
(6E)-6-[[(6-chloro-3-pyridazinyl)hydrazo]methylidene]-4-nitro-1-cyclohexa-2,4-dienone | (6E)-6-[[2-(6-chloranylpyridazin-3-yl)hydrazinyl]methylidene]-4-nitro-cyclohexa-2,4-dien-1-one | (6E)-6-[[2-(6-chloropyridazin-3-yl)hydrazinyl]methylidene]-4-nitrocyclohexa-2,4-dien-1-one | (6E)-6-[[N'-(6-chloropyridazin-3-yl)hydrazino]methylene]-4-nitro-cyclohexa-2,4-dien-1-one | 2-hydroxy-5-nitrobenzaldehyde (6-chloro-3-pyridazinyl)hydrazone | MLS000573764 | SMR000184399 | cid_6183560
Type:
Small organic molecule
Emp. Form.:
C11H8ClN5O3
Mol. Mass.:
293.666
SMILES:
[O-][N+](=O)c1ccc(=O)[c-](C[NH+]=Nc2ccc(Cl)nn2)c1 |w:10.9|
Structure:
Search PDB for entries with ligand similarity: