Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM60249
Substrate
n/a
Meas. Tech.
Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor
IC50
4065±283 nM
Citation
 PubChem, PC Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor PubChem Bioassay (2010)[AID] 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM60249
Synonyms:
3,5-dinitro-N'-[(1E)-pyridin-2-ylmethylene]benzohydrazide | 3,5-dinitro-N-(2-pyridinylmethylideneamino)benzamide | 3,5-dinitro-N-(2-pyridylmethyleneamino)benzamide | 3,5-dinitro-N-(pyridin-2-ylmethylideneamino)benzamide | MLS000720075 | SMR000304604 | cid_16193305
Type:
Small organic molecule
Emp. Form.:
C13H9N5O5
Mol. Mass.:
315.2411
SMILES:
[O-][N+](=O)c1cc(cc(c1)[N+]([O-])=O)C(=O)N\N=C\c1ccccn1
Structure:
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