Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM54825
Substrate
n/a
Meas. Tech.
Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor
IC50
2242±217 nM
Citation
 PubChem, PC Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor PubChem Bioassay (2010)[AID] 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM54825
Synonyms:
MLS000776291 | N-(4-chloranyl-3-ethyl-5-methanoyl-1,3-thiazol-2-ylidene)benzenesulfonamide | N-(4-chloro-3-ethyl-5-formyl-1,3-thiazol-2-ylidene)benzenesulfonamide | N-(4-chloro-3-ethyl-5-formyl-2-thiazolylidene)benzenesulfonamide | N-(4-chloro-3-ethyl-5-formyl-4-thiazolin-2-ylidene)benzenesulfonamide | SMR000371297 | cid_2374937
Type:
Small organic molecule
Emp. Form.:
C12H11ClN2O3S2
Mol. Mass.:
330.81
SMILES:
CCn1c(Cl)c(C=O)sc1=NS(=O)(=O)c1ccccc1
Structure:
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