Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM67320
Substrate
n/a
Meas. Tech.
Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor
IC50
3937±444 nM
Citation
 PubChem, PC Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor PubChem Bioassay (2010)[AID] 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM67320
Synonyms:
4-Bromo-3-(4-methoxy-phenylimino)-5-methyl-1,3-dihydro-indol-2-one | 4-bromanyl-3-[(4-methoxyphenyl)amino]-5-methyl-indol-2-one | 4-bromo-3-(4-methoxyanilino)-5-methyl-2-indolone | 4-bromo-3-(4-methoxyanilino)-5-methylindol-2-one | 4-bromo-5-methyl-3-(p-anisidino)indol-2-one | MLS001209842 | SMR000513370 | cid_748799
Type:
Small organic molecule
Emp. Form.:
C16H13BrN2O2
Mol. Mass.:
345.191
SMILES:
COc1ccc(NC2=c3c(Br)c(C)ccc3=NC2=O)cc1 |c:7,16|
Structure:
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