Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM67349
Substrate
n/a
Meas. Tech.
Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor
IC50
7758±1838 nM
Citation
 PubChem, PC Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor PubChem Bioassay (2010)[AID] 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM67349
Synonyms:
(3E)-5-bromo-3-[(4-methylphenyl)imino]-1,3-dihydro-2H-indol-2-one | 5-bromanyl-3-[(4-methylphenyl)amino]indol-2-one | 5-bromo-3-(4-methylanilino)-2-indolone | 5-bromo-3-(4-methylanilino)indol-2-one | 5-bromo-3-(p-toluidino)indol-2-one | MLS001197044 | SMR000555616 | cid_689509
Type:
Small organic molecule
Emp. Form.:
C15H11BrN2O
Mol. Mass.:
315.165
SMILES:
Cc1ccc(NC2=c3cc(Br)ccc3=NC2=O)cc1 |c:6,14|
Structure:
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