Reaction Details Report a problem with these data
Target
Neuropeptides B/W receptor type 1
Ligand
BDBM75936
Substrate
n/a
Meas. Tech.
Late-stage fluorescence-based dose response cell-based screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7)
IC50
1600±n/a nM
Citation
 PubChem, PC Late-stage fluorescence-based dose response cell-based screening assay to identify antagonists of the G-protein coupled receptor 7 (GPR7) PubChem Bioassay (2010)[AID] 
Target
Name:
Neuropeptides B/W receptor type 1
Synonyms:
GPR7 | NPBW1_HUMAN | NPBWR1 | neuropeptides B/W receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36111.82
Organism:
Homo sapiens (Human)
Description:
gi_119607128
Residue:
328
Sequence:
MDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
  
Inhibitor
Name:
BDBM75936
Synonyms:
SR-02000000472 | SR-02000000472-1 | [4-[5-chloranyl-3-oxidanylidene-2-(4-propan-2-ylphenyl)pyridazin-4-yl]oxyphenyl]methyl ethanoate | [4-[5-chloro-3-oxo-2-(4-propan-2-ylphenyl)pyridazin-4-yl]oxyphenyl]methyl acetate | acetic acid [4-(5-chloro-3-keto-2-p-cumenyl-pyridazin-4-yl)oxybenzyl] ester | acetic acid [4-[[5-chloro-3-oxo-2-(4-propan-2-ylphenyl)-4-pyridazinyl]oxy]phenyl]methyl ester | cid_46846321
Type:
Small organic molecule
Emp. Form.:
C22H21ClN2O4
Mol. Mass.:
412.866
SMILES:
CC(C)c1ccc(cc1)-n1ncc(Cl)c(Oc2ccc(COC(C)=O)cc2)c1=O
Structure:
Search PDB for entries with ligand similarity: