Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM76110
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay
EC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM76110
Synonyms:
1-butan-2-yl-5-ethyl-2-(ethylthio)-6-hydroxy-4-pyrimidinone | 1-butan-2-yl-5-ethyl-2-ethylsulfanyl-6-hydroxypyrimidin-4-one | 1-butan-2-yl-5-ethyl-2-ethylsulfanyl-6-oxidanyl-pyrimidin-4-one | 5-ethyl-2-(ethylthio)-6-hydroxy-1-sec-butyl-pyrimidin-4-one | MLS000106104 | SMR000103074 | cid_2843391
Type:
Small organic molecule
Emp. Form.:
C12H20N2O2S
Mol. Mass.:
256.364
SMILES:
CCSc1nc(O)c(CC)c(=O)n1C(C)CC
Structure:
Search PDB for entries with ligand similarity: