Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM54145
Substrate
n/a
Meas. Tech.
Dose Response Confirmation of compounds that inhibit VHR1 in Fluorescent Assay
IC50
2670±n/a nM
Citation
 PubChem, PC Dose Response Confirmation of compounds that inhibit VHR1 in Fluorescent Assay PubChem Bioassay (2010)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM54145
Synonyms:
5-[[3-(1,3-benzothiazol-2-yl)-4-methyl-2-thienyl]amino]-5-keto-valeric acid | 5-[[3-(1,3-benzothiazol-2-yl)-4-methyl-2-thiophenyl]amino]-5-oxopentanoic acid | 5-[[3-(1,3-benzothiazol-2-yl)-4-methyl-thiophen-2-yl]amino]-5-oxidanylidene-pentanoic acid | 5-[[3-(1,3-benzothiazol-2-yl)-4-methylthiophen-2-yl]amino]-5-oxopentanoic acid | 5-{[3-(1,3-benzothiazol-2-yl)-4-methyl-2-thienyl]amino}-5-oxopentanoic acid | MLS000850222 | SMR000456240 | cid_2811901
Type:
Small organic molecule
Emp. Form.:
C17H16N2O3S2
Mol. Mass.:
360.451
SMILES:
Cc1csc(NC(=O)CCCC(O)=O)c1-c1nc2ccccc2s1
Structure:
Search PDB for entries with ligand similarity: