Reaction Details Report a problem with these data
Target
Caspase-1
Ligand
BDBM76314
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen.
IC50
42600±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen. PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-1
Synonyms:
CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Homo sapiens (Human)
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
  
Inhibitor
Name:
BDBM76314
Synonyms:
2-(4-isopropoxyanilino)-N-(p-tolyl)acetamide | MLS000535579 | N-(4-methylphenyl)-2-(4-propan-2-yloxyanilino)acetamide | N-(4-methylphenyl)-2-[(4-propan-2-yloxyphenyl)amino]ethanamide | N~2~-(4-isopropoxyphenyl)-N~1~-(4-methylphenyl)glycinamide | SMR000143015 | cid_725331
Type:
Small organic molecule
Emp. Form.:
C18H22N2O2
Mol. Mass.:
298.3795
SMILES:
CC(C)Oc1ccc(NCC(=O)Nc2ccc(C)cc2)cc1
Structure:
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