Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM76107
Substrate
n/a
Meas. Tech.
Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor
EC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor PubChem Bioassay (2010)[AID] 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM76107
Synonyms:
1-butan-2-yl-5-ethyl-6-hydroxy-2-(propylthio)-4-pyrimidinone | 1-butan-2-yl-5-ethyl-6-hydroxy-2-propylsulfanylpyrimidin-4-one | 1-butan-2-yl-5-ethyl-6-oxidanyl-2-propylsulfanyl-pyrimidin-4-one | 3-sec-butyl-5-ethyl-6-hydroxy-2-(propylthio)-4(3H)-pyrimidinone | 5-ethyl-6-hydroxy-2-(propylthio)-1-sec-butyl-pyrimidin-4-one | MLS000058898 | SMR000069467 | cid_2842565
Type:
Small organic molecule
Emp. Form.:
C13H22N2O2S
Mol. Mass.:
270.391
SMILES:
CCCSc1nc(O)c(CC)c(=O)n1C(C)CC
Structure:
Search PDB for entries with ligand similarity: