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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM75627
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase.
EC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM75627
Synonyms:
4-Bromo-2H-pyrazole-3-carboxylic acid [1-(2-hydroxy-naphthalen-1-yl)-meth-(E)-ylidene]-hydrazide | 4-bromanyl-N'-[(Z)-(2-oxidanylidenenaphthalen-1-ylidene)methyl]-1H-pyrazole-5-carbohydrazide | 4-bromo-N'-[(Z)-(2-keto-1-naphthylidene)methyl]-1H-pyrazole-5-carbohydrazide | 4-bromo-N'-[(Z)-(2-oxo-1-naphthalenylidene)methyl]-1H-pyrazole-5-carbohydrazide | 4-bromo-N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]-1H-pyrazole-5-carbohydrazide | MLS000588004 | SMR000211991 | cid_6506002
Type:
Small organic molecule
Emp. Form.:
C15H11BrN4O2
Mol. Mass.:
359.177
SMILES:
Oc1ccc2ccccc2c1C=NNC(=O)c1[nH]ncc1Br |w:12.14|
Structure:
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