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Target
Kappa-type opioid receptor
Ligand
BDBM75579
Substrate
n/a
Meas. Tech.
SAR analysis of Antagonists of the Kappa Opioid Receptor (KOR) using an Image-Based Assay - Set 4
IC50
531±n/a nM
Citation
 PubChem, PC SAR analysis of Antagonists of the Kappa Opioid Receptor (KOR) using an Image-Based Assay - Set 4 PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM75579
Synonyms:
KSC-11-155-1 | KUC105600N | N-[2-[(phenylmethyl)-propan-2-yl-amino]ethyl]-4-[[(4-propan-2-ylphenyl)sulfonylamino]methyl]benzamide | N-[2-[(phenylmethyl)-propan-2-ylamino]ethyl]-4-[[(4-propan-2-ylphenyl)sulfonylamino]methyl]benzamide | N-[2-[benzyl(isopropyl)amino]ethyl]-4-[(p-cumenylsulfonylamino)methyl]benzamide | N-[2-[benzyl(propan-2-yl)amino]ethyl]-4-[[(4-propan-2-ylphenyl)sulfonylamino]methyl]benzamide | cid_45479162
Type:
Small organic molecule
Emp. Form.:
C29H37N3O3S
Mol. Mass.:
507.687
SMILES:
CC(C)N(CCNC(=O)c1ccc(CNS(=O)(=O)c2ccc(cc2)C(C)C)cc1)Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: