Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM60211
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
41200±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM60211
Synonyms:
4-(1-pyrrolidinylsulfonyl)-N-(8-quinolinyl)benzenesulfonamide | 4-(Pyrrolidine-1-sulfonyl)-N-quinolin-8-yl-benzenesulfonamide | 4-pyrrolidin-1-ylsulfonyl-N-quinolin-8-yl-benzenesulfonamide | 4-pyrrolidin-1-ylsulfonyl-N-quinolin-8-ylbenzenesulfonamide | 4-pyrrolidinosulfonyl-N-(8-quinolyl)benzenesulfonamide | MLS000034735 | SMR000003835 | cid_644442
Type:
Small organic molecule
Emp. Form.:
C19H19N3O4S2
Mol. Mass.:
417.502
SMILES:
O=S(=O)(Nc1cccc2cccnc12)c1ccc(cc1)S(=O)(=O)N1CCCC1
Structure:
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