Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM43347
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM43347
Synonyms:
Adamantane-1-carboxylic acid [6-(cyclopropanecarbonyl-amino)-4-methyl-pyridin-3-yl]-amide | MLS000035082 | N-[6-(cyclopropanecarbonylamino)-4-methyl-3-pyridyl]adamantane-1-carboxamide | N-[6-(cyclopropanecarbonylamino)-4-methylpyridin-3-yl]adamantane-1-carboxamide | N-[6-(cyclopropylcarbonylamino)-4-methyl-pyridin-3-yl]adamantane-1-carboxamide | N-[6-[[cyclopropyl(oxo)methyl]amino]-4-methyl-3-pyridinyl]-1-adamantanecarboxamide | SMR000005533 | cid_655663
Type:
Small organic molecule
Emp. Form.:
C21H27N3O2
Mol. Mass.:
353.458
SMILES:
[H]C12CC3([H])CC([H])(C1)CC(C2)(C3)C(=O)Nc1cnc(NC(=O)C2CC2)cc1C |TLB:8:1:12:6.9.5,8:6:12:1.11.2,THB:5:6:11:3.12.2|
Structure:
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