Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM78362
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
22500±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM78362
Synonyms:
(5Z)-2-(2-chloroanilino)-5-(2-methoxy-3-nitro-benzylidene)-2-thiazolin-4-one | (5Z)-2-(2-chloroanilino)-5-[(2-methoxy-3-nitrophenyl)methylidene]-1,3-thiazol-4-one | (5Z)-2-(2-chloroanilino)-5-[(2-methoxy-3-nitrophenyl)methylidene]-4-thiazolone | (5Z)-2-[(2-chlorophenyl)amino]-5-[(2-methoxy-3-nitro-phenyl)methylidene]-1,3-thiazol-4-one | 2-(2-Chloro-phenylimino)-5-(2-methoxy-3-nitro-benzylidene)-thiazolidin-4-one | MLS001209947 | SMR000513525 | cid_1205434
Type:
Small organic molecule
Emp. Form.:
C17H12ClN3O4S
Mol. Mass.:
389.813
SMILES:
COc1c(\C=C2/S\C([N-]C2=O)=[NH+]\c2ccccc2Cl)cccc1[N+]([O-])=O
Structure:
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