Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM60974
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
4400±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM60974
Synonyms:
MLS001291206 | N-(3-maleimidophenyl)thiophene-2-carboxamide | N-[3-(2,5-dioxo-1-pyrrolyl)phenyl]-2-thiophenecarboxamide | N-[3-(2,5-dioxopyrrol-1-yl)phenyl]thiophene-2-carboxamide | N-[3-[2,5-bis(oxidanylidene)pyrrol-1-yl]phenyl]thiophene-2-carboxamide | SMR000611660 | Thiophene-2-carboxylic acid [3-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-phenyl]-amide | cid_881135
Type:
Small organic molecule
Emp. Form.:
C15H10N2O3S
Mol. Mass.:
298.316
SMILES:
O=C(Nc1cccc(c1)N1C(=O)C=CC1=O)c1cccs1 |c:13|
Structure:
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