Reaction Details Report a problem with these data
Target
Ubiquitin-conjugating enzyme E2 N
Ligand
BDBM78214
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay
IC50
2494±165 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay PubChem Bioassay (2011)[AID] 
Target
Name:
Ubiquitin-conjugating enzyme E2 N
Synonyms:
BLU | UBE2N | UBE2N_HUMAN | ubiquitin-conjugating enzyme E2 N
Type:
PROTEIN
Mol. Mass.:
17137.61
Organism:
Homo sapiens (Human)
Description:
EBI_101440
Residue:
152
Sequence:
MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI
  
Inhibitor
Name:
BDBM78214
Synonyms:
2-[2-[4-(2-hydroxy-3-naphthalen-2-yloxypropyl)piperazin-1-yl]ethyl]benzo[de]isoquinoline-1,3-dione | 2-[2-[4-(3-naphthalen-2-yloxy-2-oxidanyl-propyl)piperazin-1-yl]ethyl]benzo[de]isoquinoline-1,3-dione | 2-[2-[4-[2-hydroxy-3-(2-naphthalenyloxy)propyl]-1-piperazinyl]ethyl]benzo[de]isoquinoline-1,3-dione | 2-[2-[4-[2-hydroxy-3-(2-naphthoxy)propyl]piperazino]ethyl]benzo[de]isoquinoline-1,3-quinone | MLS000723312 | SMR000236439 | cid_4100896
Type:
Small organic molecule
Emp. Form.:
C31H31N3O4
Mol. Mass.:
509.5955
SMILES:
OC(COc1ccc2ccccc2c1)CN1CCN(CCN2C(=O)c3cccc4cccc(C2=O)c34)CC1
Structure:
Search PDB for entries with ligand similarity: