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Target
Ubiquitin-conjugating enzyme E2 N
Ligand
BDBM48033
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay
IC50
>20000±0 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay PubChem Bioassay (2011)[AID] 
Target
Name:
Ubiquitin-conjugating enzyme E2 N
Synonyms:
BLU | UBE2N | UBE2N_HUMAN | ubiquitin-conjugating enzyme E2 N
Type:
PROTEIN
Mol. Mass.:
17137.61
Organism:
Homo sapiens (Human)
Description:
EBI_101440
Residue:
152
Sequence:
MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI
  
Inhibitor
Name:
BDBM48033
Synonyms:
2-[2-(4-methoxyphenyl)-4-oxidanylidene-pyrazolo[1,5-d][1,2,4]triazin-5-yl]-N-[3-[4-(phenylmethyl)piperidin-1-yl]propyl]ethanamide | 2-[2-(4-methoxyphenyl)-4-oxo-5-pyrazolo[1,5-d][1,2,4]triazinyl]-N-[3-[4-(phenylmethyl)-1-piperidinyl]propyl]acetamide | MLS001096036 | N-[3-(4-benzylpiperidin-1-yl)propyl]-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-d][1,2,4]triazin-5-yl]acetamide | N-[3-(4-benzylpiperidino)propyl]-2-[4-keto-2-(4-methoxyphenyl)pyrazolo[1,5-d][1,2,4]triazin-5-yl]acetamide | SMR000631163 | cid_20953588
Type:
Small organic molecule
Emp. Form.:
C29H34N6O3
Mol. Mass.:
514.6187
SMILES:
COc1ccc(cc1)-c1cc2n(cnn(CC(=O)NCCCN3CCC(Cc4ccccc4)CC3)c2=O)n1
Structure:
Search PDB for entries with ligand similarity: