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Target
Ubiquitin-conjugating enzyme E2 N
Ligand
BDBM79071
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay
IC50
12601±1209 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay PubChem Bioassay (2011)[AID] 
Target
Name:
Ubiquitin-conjugating enzyme E2 N
Synonyms:
BLU | UBE2N | UBE2N_HUMAN | ubiquitin-conjugating enzyme E2 N
Type:
PROTEIN
Mol. Mass.:
17137.61
Organism:
Homo sapiens (Human)
Description:
EBI_101440
Residue:
152
Sequence:
MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI
  
Inhibitor
Name:
BDBM79071
Synonyms:
4-Amino-isothiazole-3,5-dicarboxylic acid 3-amide 5-((2,3-dihydro-benzo[1,4]dioxin-6-yl)-{[(tetrahydro-furan-2-ylmethyl)-carbamoyl]-p-tolyl-methyl}-amide) | 4-amino-5-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-N-[1-(4-methylphenyl)-2-oxo-2-(oxolan-2-ylmethylamino)ethyl]-1,2-thiazole-3,5-dicarboxamide | 4-amino-N'-(2,3-dihydro-1,4-benzodioxin-6-yl)-N'-[2-keto-1-(p-tolyl)-2-(tetrahydrofurfurylamino)ethyl]isothiazole-3,5-dicarboxamide | 4-amino-N5-(2,3-dihydro-1,4-benzodioxin-6-yl)-N5-[1-(4-methylphenyl)-2-oxo-2-(2-oxolanylmethylamino)ethyl]isothiazole-3,5-dicarboxamide | 4-azanyl-N5-(2,3-dihydro-1,4-benzodioxin-6-yl)-N5-[1-(4-methylphenyl)-2-oxidanylidene-2-(oxolan-2-ylmethylamino)ethyl]-1,2-thiazole-3,5-dicarboxamide | MLS001221856 | SMR000599933 | cid_3180863
Type:
Small organic molecule
Emp. Form.:
C27H29N5O6S
Mol. Mass.:
551.614
SMILES:
Cc1ccc(cc1)C(N(C(=O)c1snc(C(N)=O)c1N)c1ccc2OCCOc2c1)C(=O)NCC1CCCO1
Structure:
Search PDB for entries with ligand similarity: