Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78030
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
5660±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78030
Synonyms:
1-(3-chloranyl-4-fluoranyl-phenyl)-3-[4-[(4-methoxyphenyl)amino]piperidin-1-yl]pyrrolidine-2,5-dione | 1-(3-chloro-4-fluoro-phenyl)-3-[4-(p-anisidino)piperidino]pyrrolidine-2,5-quinone | 1-(3-chloro-4-fluorophenyl)-3-[4-(4-methoxyanilino)-1-piperidinyl]pyrrolidine-2,5-dione | 1-(3-chloro-4-fluorophenyl)-3-[4-(4-methoxyanilino)piperidin-1-yl]pyrrolidine-2,5-dione | 1-(3-chloro-4-fluorophenyl)-3-{4-[(4-methoxyphenyl)amino]-1-piperidinyl}-2,5-pyrrolidinedione | MLS000052774 | SMR000082580 | cid_2983089
Type:
Small organic molecule
Emp. Form.:
C22H23ClFN3O3
Mol. Mass.:
431.888
SMILES:
COc1ccc(NC2CCN(CC2)c2cc(O)n(c2O)-c2ccc(F)c(Cl)c2)cc1
Structure:
Search PDB for entries with ligand similarity: