Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM71904
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
6280±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM71904
Synonyms:
3-Methyl-2-[2-(5-nitro-furan-2-yl)-vinyl]-3H-quinazolin-4-one | 3-methyl-2-[(E)-2-(5-nitro-2-furanyl)ethenyl]-4-quinazolinone | 3-methyl-2-[(E)-2-(5-nitro-2-furyl)vinyl]quinazolin-4-one | 3-methyl-2-[(E)-2-(5-nitrofuran-2-yl)ethenyl]quinazolin-4-one | MLS000529350 | SMR000121825 | cid_5731073
Type:
Small organic molecule
Emp. Form.:
C15H11N3O4
Mol. Mass.:
297.2655
SMILES:
Cn1c(\C=C\c2ccc(o2)[N+]([O-])=O)nc2ccccc2c1=O
Structure:
Search PDB for entries with ligand similarity: