Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78095
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
6880±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78095
Synonyms:
Heptanoic acid (2,5-dioxo-1-p-tolyl-pyrrolidin-3-yl)-hydroxy-amide | MLS000557364 | N-[1-(4-methylphenyl)-2,5-bis(oxidanylidene)pyrrolidin-3-yl]-N-oxidanyl-heptanamide | N-[2,5-diketo-1-(p-tolyl)pyrrolidin-3-yl]-N-hydroxy-enanthamide | N-hydroxy-N-[1-(4-methylphenyl)-2,5-dioxo-3-pyrrolidinyl]heptanamide | N-hydroxy-N-[1-(4-methylphenyl)-2,5-dioxopyrrolidin-3-yl]heptanamide | SMR000148281 | cid_3745707
Type:
Small organic molecule
Emp. Form.:
C18H24N2O4
Mol. Mass.:
332.3942
SMILES:
CCCCCCC(=O)N(O)c1cc(O)n(c1O)-c1ccc(C)cc1
Structure:
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