Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM61610
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
4300±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM61610
Synonyms:
(2-Methyl-[1,3]dioxan-2-yl)-acetic acid [4-(2,4-dichloro-benzyloxy)-benzylidene]-hydrazide | MLS000563840 | N-[[4-(2,4-dichlorobenzyl)oxybenzylidene]amino]-2-(2-methyl-1,3-dioxan-2-yl)acetamide | N-[[4-[(2,4-dichlorophenyl)methoxy]phenyl]methylideneamino]-2-(2-methyl-1,3-dioxan-2-yl)acetamide | N-[[4-[(2,4-dichlorophenyl)methoxy]phenyl]methylideneamino]-2-(2-methyl-1,3-dioxan-2-yl)ethanamide | SMR000175638 | cid_1087298
Type:
Small organic molecule
Emp. Form.:
C21H22Cl2N2O4
Mol. Mass.:
437.316
SMILES:
CC1(CC(=O)NN=Cc2ccc(OCc3ccc(Cl)cc3Cl)cc2)OCCCO1
Structure:
Search PDB for entries with ligand similarity: