Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78142
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
6840±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78142
Synonyms:
3-amino-6-cyclopropyl-4-(4-methoxyphenyl)-2-thieno[2,3-b]pyridinecarbonitrile | 3-amino-6-cyclopropyl-4-(4-methoxyphenyl)thieno[2,3-b]pyridine-2-carbonitrile | 3-azanyl-6-cyclopropyl-4-(4-methoxyphenyl)thieno[2,3-b]pyridine-2-carbonitrile | MLS000570501 | SMR000186927 | cid_869172
Type:
Small organic molecule
Emp. Form.:
C18H15N3OS
Mol. Mass.:
321.396
SMILES:
COc1ccc(cc1)-c1cc(nc2sc(C#N)c(N)c12)C1CC1
Structure:
Search PDB for entries with ligand similarity: