Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78173
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
19300±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78173
Synonyms:
4-nitro-N-({[2-(1-pyrrolidinyl)phenyl]amino}carbonothioyl)benzamide | 4-nitro-N-[(2-pyrrolidin-1-ylphenyl)carbamothioyl]benzamide | 4-nitro-N-[(2-pyrrolidinophenyl)thiocarbamoyl]benzamide | 4-nitro-N-[[2-(1-pyrrolidinyl)anilino]-sulfanylidenemethyl]benzamide | MLS000578317 | SMR000198217 | cid_1304063
Type:
Small organic molecule
Emp. Form.:
C18H18N4O3S
Mol. Mass.:
370.426
SMILES:
[O-][N+](=O)c1ccc(cc1)C(=O)NC(=S)Nc1ccccc1N1CCCC1
Structure:
Search PDB for entries with ligand similarity: