Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM60102
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
4100±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM60102
Synonyms:
1-(2-ethoxyphenyl)-3-[(5-phenyl-1H-1,2,4-triazol-3-yl)sulfanyl]pyrrolidine-2,5-dione | 1-(2-ethoxyphenyl)-3-[(5-phenyl-1H-1,2,4-triazol-3-yl)thio]pyrrolidine-2,5-dione | 1-(2-ethoxyphenyl)-3-[(5-phenyl-4H-1,2,4-triazol-3-yl)thio]-2,5-pyrrolidinedione | 1-o-phenetyl-3-[(5-phenyl-1H-1,2,4-triazol-3-yl)thio]pyrrolidine-2,5-quinone | MLS000677488 | SMR000271652 | cid_2927161
Type:
Small organic molecule
Emp. Form.:
C20H18N4O3S
Mol. Mass.:
394.447
SMILES:
CCOc1ccccc1-n1c(O)cc(Sc2nnc([nH]2)-c2ccccc2)c1O |(3.08,-4.21,;4.41,-4.98,;5.75,-4.21,;7.08,-4.98,;7.08,-6.52,;8.41,-7.29,;9.75,-6.52,;9.75,-4.98,;8.41,-4.21,;8.41,-2.67,;9.66,-1.76,;11.13,-2.24,;9.18,-.3,;7.64,-.3,;6.74,.95,;7.37,2.36,;6.6,3.69,;7.63,4.83,;9.03,4.21,;8.87,2.68,;10.37,4.98,;10.37,6.52,;11.7,7.29,;13.03,6.52,;13.03,4.98,;11.7,4.21,;7.17,-1.76,;5.7,-2.24,)|
Structure:
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