Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM58125
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
6440±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM58125
Synonyms:
(4E)-4-[2-[4-(diaminomethylene)cyclohexa-2,5-dien-1-ylidene]ethylidene]-3-keto-cyclohexa-1,5-diene-1-carboxamidine;2-hydroxyethanesulfonic acid | (4E)-4-[2-[4-(diaminomethylidene)-1-cyclohexa-2,5-dienylidene]ethylidene]-3-oxo-1-cyclohexa-1,5-dienecarboximidamide;2-hydroxyethanesulfonic acid | (4E)-4-[2-[4-(diaminomethylidene)cyclohexa-2,5-dien-1-ylidene]ethylidene]-3-oxocyclohexa-1,5-diene-1-carboximidamide;2-hydroxyethanesulfonic acid | (4E)-4-[2-[4-[bis(azanyl)methylidene]cyclohexa-2,5-dien-1-ylidene]ethylidene]-3-oxidanylidene-cyclohexa-1,5-diene-1-carboximidamide;2-oxidanylethanesulfonic acid | MLS000756592 | SMR000449023 | cid_5494031
Type:
Small organic molecule
Emp. Form.:
C16H16N4O
Mol. Mass.:
280.3244
SMILES:
NC(N)=c1ccc(=C\C=C2/C=CC(=CC2=O)C(N)=N)cc1 |c:10,12,(5.33,15.58,;4,14.81,;2.67,15.58,;4,13.27,;5.33,12.5,;5.33,10.96,;4,10.19,;4,8.65,;2.67,7.88,;2.67,6.34,;4,5.57,;4,4.03,;2.67,3.26,;1.33,4.03,;1.33,5.57,;,6.34,;2.67,1.72,;4,.95,;1.33,.95,;2.67,10.96,;2.67,12.5,)|
Structure:
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