Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM58233
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
1310±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM58233
Synonyms:
2-amino-2-sulfanylidene-N-[4-(trifluoromethoxy)anilino]ethanimidoyl cyanide | 2-cyano-2-[[4-(trifluoromethoxy)phenyl]hydrazinylidene]ethanethioamide | 2-cyano-2-[[4-(trifluoromethoxy)phenyl]hydrazono]thioacetamide | 2-cyano-2-[[4-(trifluoromethyloxy)phenyl]hydrazinylidene]ethanethioamide | 2-cyano-2-{2-[4-(trifluoromethoxy)phenyl]hydrazono}ethanethioamide | MLS000834858 | SMR000461374 | cid_2744440
Type:
Small organic molecule
Emp. Form.:
C10H7F3N4OS
Mol. Mass.:
288.249
SMILES:
NC(=S)C(=NNc1ccc(OC(F)(F)F)cc1)C#N |w:4.4|
Structure:
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