Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78386
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
6940±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78386
Synonyms:
2,4,5-trimethoxybenzoic acid [(Z)-[amino(p-tolyl)methylene]amino] ester | 2,4,5-trimethoxybenzoic acid [(Z)-[amino-(4-methylphenyl)methylidene]amino] ester | 4-methyl-N'-[(2,4,5-trimethoxybenzoyl)oxy]benzenecarboximidamide | MLS001198523 | SMR000558941 | [(Z)-[amino-(4-methylphenyl)methylidene]amino] 2,4,5-trimethoxybenzoate | [(Z)-[azanyl-(4-methylphenyl)methylidene]amino] 2,4,5-trimethoxybenzoate | cid_9587683
Type:
Small organic molecule
Emp. Form.:
C18H20N2O5
Mol. Mass.:
344.3618
SMILES:
COc1cc(OC)c(cc1OC)C(=O)ON=C(N)c1ccc(C)cc1 |w:15.15|
Structure:
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