Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78391
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
1550±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78391
Synonyms:
MLS001167416 | N-(6-methyl-2-pyridinyl)-5-nitro-2-thiophenecarboxamide | N-(6-methyl-2-pyridyl)-5-nitro-thiophene-2-carboxamide | N-(6-methylpyridin-2-yl)-5-nitro-thiophene-2-carboxamide | N-(6-methylpyridin-2-yl)-5-nitrothiophene-2-carboxamide | SMR000640705 | cid_3662576
Type:
Small organic molecule
Emp. Form.:
C11H9N3O3S
Mol. Mass.:
263.272
SMILES:
Cc1cccc(NC(=O)c2ccc(s2)[N+]([O-])=O)n1
Structure:
Search PDB for entries with ligand similarity: