Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM59078
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
5090±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM59078
Synonyms:
(E)-4-(9,10-dihydrophenanthren-2-yl)-4-keto-but-2-enoic acid | (E)-4-(9,10-dihydrophenanthren-2-yl)-4-oxidanylidene-but-2-enoic acid | (E)-4-(9,10-dihydrophenanthren-2-yl)-4-oxo-2-butenoic acid | (E)-4-(9,10-dihydrophenanthren-2-yl)-4-oxobut-2-enoic acid | MLS001240897 | SMR000841241 | cid_5905739
Type:
Small organic molecule
Emp. Form.:
C18H14O3
Mol. Mass.:
278.302
SMILES:
OC(=O)\C=C\C(=O)c1ccc-2c(CCc3ccccc-23)c1
Structure:
Search PDB for entries with ligand similarity: