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Target
Neurotensin receptor type 1
Ligand
BDBM70875
Substrate
n/a
Meas. Tech.
Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1
EC50
6690±n/a nM
Citation
 PubChem, PC Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1 PubChem Bioassay (2011)[AID] 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM70875
Synonyms:
(Z)-2-(1,3-benzothiazol-2-yl)-N-(4-chlorophenyl)-3-(3-hydroxyphenyl)-2-propenamide | (Z)-2-(1,3-benzothiazol-2-yl)-N-(4-chlorophenyl)-3-(3-hydroxyphenyl)acrylamide | (Z)-2-(1,3-benzothiazol-2-yl)-N-(4-chlorophenyl)-3-(3-hydroxyphenyl)prop-2-enamide | MLS000392964 | SMR000248103 | cid_8259799
Type:
Small organic molecule
Emp. Form.:
C22H15ClN2O2S
Mol. Mass.:
406.885
SMILES:
Oc1cccc(\C=C(\C(=O)Nc2ccc(Cl)cc2)c2nc3ccccc3s2)c1
Structure:
Search PDB for entries with ligand similarity: