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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM79891
Substrate
n/a
Meas. Tech.
Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1)
IC50
5262±n/a nM
Citation
 PubChem, PC Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1) PubChem Bioassay (2011)[AID] 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM79891
Synonyms:
(3,5-dimethyl-1-phenyl-4-pyrazolyl)-bis(1-ethenyl-2-imidazolyl)-sulfanylidenephosphorane | (3,5-dimethyl-1-phenyl-pyrazol-4-yl)-bis(1-ethenylimidazol-2-yl)-sulfanylidene--phosphane | (3,5-dimethyl-1-phenyl-pyrazol-4-yl)-thioxo-bis(1-vinylimidazol-2-yl)phosphorane | (3,5-dimethyl-1-phenylpyrazol-4-yl)-bis(1-ethenylimidazol-2-yl)-sulfanylidene--phosphane | MLS000879924 | SMR000060622 | cid_2999024
Type:
Small organic molecule
Emp. Form.:
C21H21N6PS
Mol. Mass.:
420.47
SMILES:
Cc1nn(c(C)c1P(=S)(c1nccn1C=C)c1nccn1C=C)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: