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Target
DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM46679
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
15400±n/a nM
Comments
extracted
Citation
 PubChem, PC Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] 
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
  
Inhibitor
Name:
BDBM46679
Synonyms:
(4-chlorodithiazol-5-ylidene)-(2,5-dimethoxyphenyl)amine | 4-chloranyl-N-(2,5-dimethoxyphenyl)-1,2,3-dithiazol-5-imine | 4-chloro-N-(2,5-dimethoxyphenyl)-5-dithiazolimine | 4-chloro-N-(2,5-dimethoxyphenyl)dithiazol-5-imine | MLS-0390822.0001 | cid_483894
Type:
Small organic molecule
Emp. Form.:
C10H9ClN2O2S2
Mol. Mass.:
288.774
SMILES:
COc1ccc(OC)c(c1)\N=c1\ssnc1Cl
Structure:
Search PDB for entries with ligand similarity: